History Of Adderall
Adderall is a drug, which is widely prescribed for the people suffering from attention deficit hyperactivity disorder and narcolepsy. It is a psycho stimulant drug that belongs to the chemical classes of amphetamine and phenethylamine. It is the combination of four different amphetamine salts such as racemic amphetamine sulfate, racemic amphetamine aspirate monohydrate, dextroamphetamine sulfate and dextroamphetamine saccharide. It is available in both the formulations of instant release (IR) and extended release (XR). While the former is used for treating both ADHD and narcolepsy, the latter is approved only for the usage by people suffering from attention deficit hyperactivity disorder (ADHD). Adderall is also used for treating obesity. However, the pharmacists of the American Society of Health System do not recommend its usage. It is also known to have used for curing patients with severe depression in certain situations.
The usage of amphetamine is widely in practice for a very long time. However, amphetamine became available with the brand of Adderall only in 1996. At that time of the release of this drug, it was only available in instant release formulation. It was by same compound like the Obetrol, which was once a very famous diet drug. Later in 2001, the drug became available in the extended release formulation too which is called as Adderall XR. This was the product of the company Shire Pharmaceuticals Group which is a pharmaceutical manufacturer in Britain. The patent for the Adderall extended release (XR) was given to Shire Pharmaceuticals only till 2007. Till then the exclusive rights to produce it were allowed to be held by Shire alone after which it was supposed to expire. However, this has not happened and Shire has continued to retain its patent rights by delaying it through litigation. Though it is expected to end in 2018, the exact status regarding the expiry is still unknown. Because of various issues that have cropped up because of this, Shire had to agree for Barr producing the generic form of Adderall. Both of them had entered an agreement as a result of which Barr started manufacturing the generic form of it from April 1, 2009.
The drug is available for usage in 5, 10, 15, 20, 25 and 30 milligrams doses. The United Nations Convention on Psychotropic Substances regulated the international usage of the amphetamine salts and Adderall can be obtained only by prescription in all UN countries. Some of the sources state that Shire pharmaceutical is presently involved in the production of another formulation, which is an even greater variation of the Adderall extended release formulation. This formulation is known to contain three different beads so that it can give three doses in the day while the earlier version used to deliver only two. This is because many those who have used it have felt that one extended release pill is not sufficient to make them comfortable for the whole day. They also say that it is just enough for eight hours of work making it essential to take an instant release pill after that to feel better.
Currently, the Teva and Barr Pharmaceuticals is involved in the production of Adderall IR while Shire, the creator of its ceased its manufacture. However, it still continues to produce the XR formulation of Adderall. Shire has sold the rights for the usage of the name Adderall for instant release version to DuraMed Pharmaceuticals in 2006. Teva Pharmaceuticals have acquired DuraMed Pharmaceuticals later in 2008 after the purchase of Barr Pharmaceuticals. With the change in the manufacturers, the “imprint” on the tablets of Adderall IR has also witnessed change. The earlier imprint “AD” is replaced with the lowercase letter “d” over the lowercase letter “p”.
Adderall is declared as schedule II because of being highly addictive and posing risks of abuse. Because of having an amphetamine base, it has produced a number of side effects on the patients. While the common side effects among children starting with minor ones are loss of appetite, trouble in sleeping, insomnia, head ache, stomach pain etc extending up to major problems of kidney failure. Similarly, among the adults the common side effects are stomach pain, decreased appetite, dry mouth, extreme irritability and mood swings, severe headache, depression and many more.